After a course in theatrical design at Medway College of Art in Rochester, Keith Wilson went straight to AP Films, working as Bob Bell's assistant on Fireball XL5 and succeeding series. He was recruited in January 1973 to assemble sketches for Space: 1999. Outside Anderson series, he worked on The Revenge Of Dr Death (released as Madhouse, 1974), and the series Star Maidens (1975) and The New Avengers (1977). He then worked on the films International Velvet (1978) and The Day Christ Died (1980), and the series Worlds Beyond (1986). Later work has been in TV miniseries, often Biblical or Dickens adaptations with director Kevin Connor. Miniseries have included Great Expectations (1989), Stalin (1992, won an Emmy award for art direction), The Old Curiosity Shop (1994, won a Cable Ace Award for art direction), Oliver Twist (1997), Mary, Mother Of Jesus (1999), In The Beginning (2000, which featured a number of cast and crew from Space 1999 including director Kevin Connor, writer John Goldsmith, stars Martin Landau and Christopher Lee), A Christmas Carol (2004), The Ten Commandments (2006), Love and Virtue (2008) and Crossmaglen (2011).
He painted illustrations for the book The Tree of Seasons by Stephen Gately (2010).
Wilson attended conventions in 1995 (UK), 1996 (UK), 2000 (USA), 2005 (UK), 2006 (Italy), 2007 (UK).
An on-set interview from 1976 can be seen on the Carlton DVDs (also on the A&E bonus disc). The Space: 1999 Documentary (1996) contains an interview, extracts of which appear on the Network DVD set (2005). An interview Keith Wilson, Life Beyond Alpha by Peter Halpin was released on YouTube in 2010.